Oh, I really like this poster. Such a distinctive image, it immediately stands out. And the use of this tagline together with the out of focus image of George Clooney is very, very clever, and it give us a good feel for what the film is going to be like and the general themes it will approach. This is an example of big letters done right: short sentence, easy to read and related to the rest of the image.
And I love that they managed to use the face of the star in a creative way. More of that, please!
Andrew over at Movie Patron blog says this reminds him of a book cover. Me too, although in the book the red letters would probably contain the title. Now, not all good book covers would make for a good poster. But I think this design would work in both mediums. Which makes it even more interesting.